BFR1 — Candida albicans

Summary

C5_05080W_A (BFR1, also known as GRF10) on Candida albicans chromosome 5 encodes a homeodomain-containing protein with RNA polymerase II-specific DNA-binding and transcription activator activity. The protein localises to the nucleus and is associated with the regulation of filamentous growth, hyphal growth, biofilm formation, chlamydospore formation, morphogenesis, and cell differentiation. It is associated with copper ion homeostasis, response to copper, activation of purine nucleotide and AMP anabolism, adenine anabolism, nucleotide metabolism, one-carbon metabolism, phosphate metabolism, and deubiquitination. The gene is also linked to anterior/posterior axis specification. Studies of related genes in other species link them to a RING-type E3 ubiquitin ligase domain and to traits including reduced virulence, oxidative stress response, and acid sensitivity.