PGK — Candida albicans

Summary

Candida albicans PGK1 (C6_00750C_A) encodes a phosphoglycerate kinase, an enzyme with phosphoglycerate kinase activity (EC 2.7.2.3) that binds ADP, ATP and metals. The gene is associated with canonical glycolysis, gluconeogenesis, and the glycolytic process, as well as with ROS metabolic processes, cell wall assembly, protein secretion, flocculation, and cell cycle phases including G1 and M phase. PGK1 is linked to host interaction processes such as inflammatory and immune responses, immune evasion, host invasion, and perturbation of host immune response. It is associated with traits including respiration rate and phenotypes such as increased adhesion, increased mating efficiency, decreased cell death, abnormal replicative lifespan, and altered cell cycle progression. The protein localises to the cytoplasm, cell wall, plasma membrane, mitochondria, and biofilm matrix.