EBP1 — Candida albicans

Summary

C6_01180C_A (EBP1, also known as OYE2, CaOYE2, CaMIG-3, CaOYE3, OYE3, MIG-3) in Candida albicans chromosome 6 encodes a protein with 2-enoate reductase activity, NADPH dehydrogenase activity, and FMN binding, belonging to the Oye-like and OxRdtase_FMN_N families. It is associated with hormone, estrogen, and steroid binding, and linked to steroid metabolism, indole alkaloid anabolism, electron transport, aerobic respiration, fermentation, carbohydrate metabolism, cell cycle, morphogenesis, biofilm formation, apoptosis, and cytoskeleton organization. The gene product localizes to the hyphal cell wall and fungal-type vacuole. Associations include oxidative stress response, abnormal cell cycle progression (including G1 and G2/M arrest), abnormal cellular morphology, decreased budding and anaerobic growth, increased telomere length, and altered apoptosis. Related genes in other species link the family to similar metabolic and stress-response processes.