MIP1 — Candida albicans

Summary

CaMIP1 (C6_01550C_A) in Candida albicans encodes a DNA-directed DNA polymerase with 3'-5' exonuclease activity, belonging to the DNA polymerase A family and localising to the mitochondrial gamma DNA polymerase complex. The gene is associated with mitochondrial DNA replication and breakdown, as well as diverse biological processes including inflammatory and immune responses, chemotaxis, phagocytosis, quorum sensing, and cellular response to nitrogen starvation. Phenotypic associations link CaMIP1 to mitochondrial genome maintenance, cell cycle progression in S phase, mutation frequency, pseudohyphal growth, biofilm formation, telomere length, UV and gamma ray resistance, alkaline pH resistance, and utilisation of carbon and nitrogen sources. Studies of related genes in other species connect the family to oxidative stress response and respiratory metabolism.