ABC2 — Candida albicans

Summary

ABC2 (MDL2) on Candida albicans chromosome 6 encodes an ABC-type oligopeptide transporter with ATP hydrolase activity and ATP-coupled transmembrane transporter activity, belonging to the type 1 exporter family. The gene is associated with diverse biological processes including fluconazole transport, ergosterol metabolism, phospholipid transport, germ tube formation, quorum sensing, phagocytosis, response to ethanol, and sulfur amino acid metabolism. It localises to the mitochondrial inner membrane, mitochondria, and plasmalemma. Phenotypic associations link ABC2 to altered oxidative and osmotic stress resistance, decreased endocytosis, abnormal vacuolar morphology and distribution, increased pexophagy, and changes in cell cycle progression, including increased G2/M phase transition and entry into G0. The gene is also connected to protein/peptide accumulation rates and abnormal nuclear export.