POX1 — Candida albicans

Summary

Candida albicans POX1 (CaPOX1) on chromosome 6 encodes an acyl-CoA oxidase with EC 1.3.3.6 activity, conferring acyl-CoA oxidase activity, fatty acid binding, and FAD binding. The product localizes to the peroxisome and is associated with fatty acid beta-oxidation, lipid homeostasis, eoxin synthesis, arachidonic acid metabolism, prostaglandin anabolism, biofilm formation, fermentation, homologous recombination, the G2 phase, and the cell cycle. POX1 is associated with numerous phenotypes including decreased biofilm formation, decreased filamentous and invasive growth, abnormal or absent vegetative growth, increased innate thermotolerance and metal resistance, altered chronological lifespan, decreased nutrient uptake and utilization, decreased survival in stationary phase, and increased RNA accumulation. Related genes in other species connect the family to oxidative stress response and acid sensitivity.