ABC2 — Candida albicans

Summary

C6_04210C_A (ABC2, ATM1) on chromosome 6 of Candida albicans encodes an ABC transporter with ATP-coupled transmembrane transporter activity, ATP hydrolase activity, and identical protein binding, belonging to the type 1 exporter family. The gene is associated with mitochondrial inner membrane localization and linked to iron-sulfur cluster export from the mitochondrion, sulfur amino acid metabolism, ergosterol metabolism, phospholipid transport, fluconazole transport, germ tube formation, quorum sensing, and response to ethanol. It has been connected to oxidative stress response, decreased hyperosmotic and hypo-osmotic stress resistance, abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, altered cell cycle progression, decreased fermentative metabolism, and increased entry into G0 stationary phase.