SOD2 — Candida albicans

Summary

SOD2 (also known as SOD3) on Candida albicans chromosome 7 encodes a manganese/iron superoxide dismutase (EC 1.15.1.1) with superoxide dismutase activity, manganese binding and IgE binding. The protein localises to the mitochondrial lumen, mitochondria and cytosol. The gene is associated with response to glutathione, regulation of K+ transport, evasion or tolerance of host-produced AOS, response to host, metabolic burst, wound healing, germ tube formation, quorum sensing, innate immunity, immune response, removal of O2-, glycerol anabolism, ATP anabolism, protein unfolding, and response to glucose. It is linked to numerous phenotypes including increased necrotic cell death, increased fermentative growth, absent mating type switching, increased hydrostatic pressure and freeze-thaw resistance, decreased radiation and pheromone sensitivity, increased alkaline pH resistance, and abnormal septum and spore wall formation.