HSC82 — Candida albicans

Summary

C7_02030W_A (HSC82, also known as HSP90) in Candida albicans encodes an ATP-dependent protein folding chaperone belonging to the Hsp90 family, with ATP hydrolase activity and identical protein binding capability. This gene is associated with diverse biological processes including cell wall repair, regulation of telomere maintenance, response to oxygen levels, PKC signal transduction, and regulation of apoptosis. It has been linked to hyphal cell wall and extracellular vesicle localisation. Phenotypic associations include altered cell cycle progression, increased thermotolerance, abnormal flocculation, premature apoptosis, absent biofilm formation, and decreased hypoosmotic stress resistance. Studies of related genes in other species link the family to increased virulence.