NRG1 — Candida albicans

Summary

C7_04230W_A (NRG1) in Candida albicans encodes a C2H2-type zinc-finger protein with DNA-binding transcription repressor activity, and RNA polymerase II cis-regulatory region sequence-specific DNA binding. This gene is associated with cell fate specification, filament development, cell migration, and spindle orientation, as well as responses to farnesol, staurosporine, N-acetyl-D-glucosamine, and the host environment. It is linked to regulation of carbon utilization, nitrogen catabolite repression, arginine breakdown, chitin anabolism, and the oxidative branch of the pentose pathway, along with negative regulation of isoprenoid metabolism and downregulation of transcription by glucose. The protein localizes to the nucleus, cytoplasm, chromatin, and transcription regulator complexes. NRG1 has been connected to invasive and disseminated candidiasis. Studies of related genes in other species link the family to carbon catabolite repression.