ACUF — Candida albicans

Summary

The Candida albicans gene CR_00200W_A (symbol ACUF, also known as PCK1) encodes phosphoenolpyruvate carboxykinase (ATP) (EC 4.1.1.49), an enzyme with ATP binding activity. This cytosolic protein contains PEP carboxykinase ATP-binding and C-terminal domains. The gene is associated with gluconeogenesis, the glyoxylate cycle, TCA cycle, citrate and acetate metabolism, and alternative respiration. It is linked to filamentous growth, morphogenesis, ergosterol anabolism, centromere separation, mitosis, anaphase, and detoxification. Phenotypic associations include absent anaerobic and filamentous growth, increased alkaline pH and ionic stress resistance, increased entry into G0, abnormal colony shape and cell size, decreased nutrient uptake, and premature cell cycle progression through metaphase and telophase. Studies of related genes in other species link the family to carbon source utilisation.