DAL81 — Candida albicans

Summary

CR_01030W_A (DAL81) on Candida albicans chromosome 8 encodes a transcription coactivator with DNA-binding and lyase activities, belonging to the Zn2Cys6 fungal-type DNA-binding superfamily. The gene is associated with nitrogen catabolite repression and activation of urea and GABA catabolism, as well as regulation of pH, gluconeogenesis, hexose breakdown, arginine metabolism, and iron transport. It has been linked to biofilm formation, cell-substrate adhesion, and pseudohyphal growth. Localization evidence connects the product to the nucleus, cytosol, and vacuole. Phenotypic associations include altered nitrogen and sulfur utilization, increased alkaline pH and hydrostatic pressure resistance, decreased apoptosis and mutation frequency, abnormal cell cycle progression, and increased respiratory metabolism. Related genes in other species link the family to nutrient utilization and filamentous growth.