ACP1 — Candida albicans

Summary

CR_01180W_A (ACP1, also known as CAP01) in Candida albicans encodes an F-actin-binding protein belonging to the CapZ alpha family, a component of the F-actin capping protein complex. The gene is associated with barbed-end actin filament capping, actin cortical patch organization, and localization to the cellular bud tip, cortical cytoskeleton, and mitotic actomyosin contractile ring. ACP1 is linked to numerous biological processes including hexose breakdown, autophagy of peroxisomes, macrophage activation, detoxification of hydrogen peroxide, regulation of secretion, and cAMP anabolism. Phenotypic associations connect the gene to cell cycle progression, endocytosis, filamentous growth, pseudohyphal growth, cytokinesis, bipolar budding pattern, mating efficiency, mitophagy, and survival rate in stationary phase. It is also linked to oxidative stress response, acquired thermotolerance, and increased fermentative metabolism. Studies of related genes in other species associate the family with reduced virulence and altered protein secretion.