DMC1 — Candida albicans

Summary

CR_02200C_A (DMC1, also known as RAD51, MEI-3, CaRAD51, CaMEI-3, or CaDMC1) on Candida albicans chromosome 8 encodes a recombinase with ATP-dependent DNA damage sensor activity, ATPase activity acting on DNA, and ATP hydrolase activity, belonging to the RecA/Rad51 family of DNA recombination and repair proteins. The gene is associated with meiotic strand invasion, double-strand break repair involved in meiotic recombination, meiotic joint molecule formation, and meiotic gene conversion, as well as mitotic recombination-dependent replication fork processing, mating-type switching, and regulation of filamentous growth. It localizes to condensed nuclear chromosomes, centromere complexes, sites of double-strand breaks, and the nuclear envelope. Phenotypic associations include absent X-ray resistance, absent mitotic recombination, absent sporulation efficiency, delayed exponential-phase growth, and increased gamma-ray resistance. Related genes in other species link the family to meiotic recombination processes.