BSC1 — Candida albicans

Summary

CR_02640W_A (BSC1, also known as RFG1) on Candida albicans chromosome 8 encodes a protein with an SRY-related HMG-box domain. The product is a sequence-specific DNA-binding protein that bends DNA, activates RNA polymerase II transcription, and acts as a transcription coactivator. BSC1 is associated with filament development, germ tube formation, flocculation, biofilm formation, mating type determination, and response to farnesol and basic pH. It is linked to regulation of chitin anabolism, meiotic cell cycle progression, and TNF production. Phenotypic associations include abnormal biofilm formation, increased adhesion, altered flocculation, premature meiosis, increased polyploidy, and increased mating efficiency. The protein localizes to the nucleus, chromatin, and RNA polymerase II transcription regulator complex.