PP4 — Candida albicans

Summary

CR_03800C_A (PP4, also known as PPH3) in Candida albicans chromosome 8 encodes a protein serine/threonine phosphatase with metal-binding activity, classified as EC 3.1.3.16 and belonging to the calcineurin-like and metallo-dependent phosphatase families. The gene is associated with protein dephosphorylation, regulation of TORC1 signaling, the septation initiation network, and filamentous growth in response to chemical stimulus, neutral pH, and heat. It is linked to cell cycle processes including G2/M phase progression, metaphase-anaphase transition, chromosome segregation, and anaphase cohesion protection, as well as negative regulation of DNA damage checkpoint, positive regulation of non-homologous end joining, and meiotic recombination. Phenotypic associations include increased virulence, decreased polyploidy, abnormal aneuploidy, abnormal chronological lifespan, delayed autophagy, and increased adhesion. The protein localizes to the nucleus, cytoplasm, chromatin, nuclear periphery, and the PP4 and PP2A complexes.