PMB — Candida albicans

Summary

CR_05020W_A (PMB, also known as LYP1, ALP1, or CAN1) on Candida albicans chromosome 8 encodes a basic amino acid permease belonging to the APC_YAT and AA-permease/SLC12A_dom families, with molecular functions including L-proline, L-histidine, L-arginine, and L-lysine transmembrane transporter activity, as well as amino acid binding and permease activity. The gene is associated with amino acid transport, proline import, basic amino acid transport, nitrogen catabolite repression, plasma membrane organization, response to heat and stress, single-species biofilm formation, and sphingolipid and glucan anabolism. It localizes to the plasma membrane, eisosome, fungal-type cell wall, Golgi, and ER. Phenotypic associations include abnormal nitrogen utilization, increased pseudohyphal growth, decreased apoptosis, altered cell cycle progression, increased polyploidy and aneuploidy, decreased cold sensitivity, and altered nutrient uptake. Studies of related genes in other species link the family to reduced virulence and altered biofilm formation.