MNT1 — Candida albicans

Summary

CR_05290W_A (MNT1, also known as MNT3) on Candida albicans chromosome 8 encodes a protein with mannosylphosphate transferase and alpha-1,2-mannosyltransferase activities, belonging to the Glyco_trans_15 and Nucleotide-diphossugar_trans families. The gene is associated with protein O-linked and N-linked glycosylation, mannan and cell wall mannoprotein anabolism, cell wall biogenesis and organization, biofilm formation, cell-matrix and cell-cell adhesion, secretion, asexual sporulation, phagocytosis, immune response, and mitigation of host defenses. It is also associated with interaction with host and is localized to the Golgi membrane, ER membrane, plasma membrane, cytoplasm, cytosol, nucleus, and extracellular space. Related genes in other species are linked to reduced virulence and candidiasis.