PREB — Candida albicans

Summary

CR_06610W_A (PREB, also known as STE2) on Candida albicans chromosome 8 encodes a G-protein-coupled receptor (GPCR) of the STE2 family with mating-type alpha-factor pheromone receptor activity. This gene is associated with mating, sexual reproduction, karyogamy, and the GPCR signaling pathway, as well as response to pheromone triggering conjugation with cellular fusion. It has been linked to biofilm formation, cell-substrate and cell-cell adhesion, phenotypic switching, morphogenesis, and signal transduction. Phenotypic associations include altered mating efficiency, pheromone sensitivity and production, cell fusion, shmoo formation, endocytosis, vesicle distribution, vacuolar transport, nuclear fusion during mating, cell cycle progression, budding rate, and protein transport and accumulation. The gene is also connected to regulators such as MF(ALPHA)1, MF(ALPHA)2, STE3, and MATALPHA2. Studies of related genes in other species link the family to oxidative stress response.