DIS2 — Candida albicans

Summary

CR_07650W_A (DIS2, also known as GLC7) on Candida albicans chromosome 8 encodes a serine/threonine protein phosphatase catalytic subunit, a member of the PP1 family with metal-binding and RNA polymerase II C-terminal domain T4 phosphatase activity. This gene is associated with the regulation of cell budding, cell polarization, anisotropic cell growth, and positive regulation of clathrin-mediated endocytosis. It is linked to glycogen anabolism, mitotic cell cycle modulation, centromere clustering, and protein localization to kinetochores. Localization evidence places the product at the cellular bud neck septin collar, cell cortex of growing and non-growing cell tips, and within the PTW/PP1 phosphatase complex. Phenotypic associations include abnormal filamentous growth, cell cycle progression defects, and altered stress resistance, including alkaline pH and desiccation resistance. Related genes in other species link the family to the DPS complex.