FHPA — Candida albicans

Summary

CR_07810W_A (FHPA, also known as YHB5) in Candida albicans encodes a nitric oxide dioxygenase with NAD(P)H activity, a heme- and FAD-binding globin-domain protein that localises to mitochondria, cytoplasm, cytosol and nucleus. The gene is associated with nitric oxide breakdown, response to nitrosative and oxidative stress, alternative respiration, glyoxylate cycle regulation, gluconeogenesis, biofilm formation, germ tube formation, phenotypic switching, cell adhesion, phagocytosis, sterol metabolism and heterotrophy. Phenotypic associations include increased flocculation, increased mating response, increased autophagy, increased hyperosmotic stress resistance, increased chitin deposition and telomere length, decreased fermentative and respiratory metabolism, decreased gamma ray resistance, decreased freeze-thaw resistance, decreased stationary phase survival, absent pseudohyphal growth, absent mitochondrial genome maintenance, abnormal budding and endomembrane morphology, and cell cycle arrest at G1 and G2/M phases. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.