ABC2 — Candida albicans

Summary

CR_08200C_A (CaABC2) on Candida albicans chromosome 8 encodes an ABC transporter with cadmium ion transmembrane transporter, haem-transporting ATPase, and ABC-type phytochelatin transporter activities, and is associated with ATP binding and hydrolase activity. The protein localises to the vacuolar membrane, fungal-type vacuole, Golgi complex, endoplasmic reticulum, plasmalemma, and extracellular vesicles. CaABC2 is associated with fluconazole transport, cellular detoxification of cadmium ion, heme export from vacuole to cytoplasm, glutathione transport into vacuole, PC2 import into vacuole, germ tube formation, ergosterol metabolism, nitrogen utilization, sulfur amino acid metabolism, and mRNA transcription. Associations with oxidative stress response, vacuolar morphology, endocytosis, cell cycle progression, and hyperosmotic stress resistance have been noted. Studies of related genes in other species connect the family to vacuolar transport and stress responses.