TRX — Candida albicans

Summary

CR_10350C_A, designated TRX1 in Candida albicans and located on chromosome 8, encodes a thioredoxin domain-containing protein with protein-disulfide reductase and antioxidant activities. The gene is associated with cell redox homeostasis, regulation of the cellular response to oxidative stress, and cellular detoxification of hydrogen peroxide. TRX1 is linked to vacuole inheritance, phospholipid transport, nitrogen utilization, and the response to iron. It is also associated with innate immunity, phagocytosis, and defecation. Phenotypic associations include increased adhesion, decreased cell death, increased survival in stationary phase, decreased exponential-phase growth, abnormal colony color and shape, delayed or absent cytokinesis, abnormal autophagy and septum formation, decreased fermentative and respiratory metabolism, and increased mating response. The protein localizes to the cytoplasm, nucleus, vacuole, and fungal biofilm matrix.