ERG2 — Candida albicans

Summary

Candida albicans ERG2 (C1_00800C_A) encodes a C-8 sterol isomerase. The gene is associated with ergosterol metabolism and anabolism, as well as sterol import, sphingolipid anabolism, and lipid homeostasis. ERG2 is linked to biofilm formation, hyphal growth, and cellular responses to xenobiotic stimuli. It is localized to the ER membrane. The gene is associated with abnormal plasma membrane morphology, increased cell death, decreased mating response, abnormal cell cycle progression, and increased flocculation. Associations with cell membrane stability and protein content have also been noted. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.