DO — Candida albicans

Summary

C1_02420C_A (DO, also known as GSC1, FKS1, and CaBGS1) in Candida albicans encodes a protein with branched 1,3-beta-D-glucan synthase activity, callose synthase activity, and a-1,3-glucan synthase activity. This gene is associated with fungal-type cell wall polysaccharide biosynthesis, primary and secondary cell septum biogenesis, ascospore wall 1,3-beta-glucan anabolism, and mitotic division septum assembly. It is linked to response to micafungin, inflammatory response, IL-1 production, cell aggregation, differential growth, and regulation of establishment or maintenance of cell polarity regulating cell shape. The encoded protein localizes to the 1,3-beta-glucan synthase complex, primary cell septum, cleavage furrow, new growing cell tip, old growing cell tip, cell cortex of growing cell tip, and site of polarized growth. Associations with oxidative stress response, alkaline pH resistance, adhesion, spore germination, and cell cycle progression through the G2/M phase transition have been noted.