IFD6 — Candida albicans

Summary

C1_04140W_A (IFD6) on Candida albicans chromosome 1 encodes a protein in the AKR_Detox_Biosynth and NADP_OxRdtase_dom families, with aryl-alcohol dehydrogenase (NAD+) activity, versiconal reductase activity, versiconal hemiacetal acetate reductase activity, and hydroxyversicolorone reductase activity. The gene is associated with seed germination, cell aggregation, quorum sensing, biofilm formation, hyphal growth, morphogenesis, cell adhesion, glucan anabolism, potassium ion membrane transport, and cell growth. Its product localizes to the fungal biofilm matrix, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence, increased chemical resistance, decreased competitive fitness, oxidative stress response, and candidiasis.