ERG3 — Candida albicans

Summary

C1_04770C_A (ERG3) on Candida albicans chromosome 1 encodes a sterol-C5-desaturase (lathosterol oxidase, EC 1.14.19.20) with iron-binding activity, belonging to the Sterol_Desaturase_Related and fatty acid hydroxylase families. This gene is associated with sterol metabolism, anabolism and homeostasis, as well as lipid homeostasis, biofilm formation, filamentous growth, quorum sensing, cell adhesion, oxidative phosphorylation, mitotic recombination, and regulation of gene expression. It is linked to chemokine and IL-1 production, demethylation, phototropism, and glucan anabolism. The product localises to the ER lumen, Golgi complex, ER membrane, ER, and plasmalemma. ERG3 is associated with vaginal, oropharyngeal and disseminated candidiasis. Related genes in other species link the family to calcium and acid sensitivity, potassium concentration, oxidative stress response, and increased biofilm formation.