SAP7 — Candida albicans

Summary

C1_04870W_A (SAP7) on Candida albicans chromosome 1 encodes an aspartic endopeptidase (EC 3.4.23.24) with aspartic endopeptidase activity and metal binding, belonging to the aspartic peptidase A1 family. This gene is associated with fibrinolysis, blood clotting, fatty acid oxidation, glyoxylate cycle, protein processing, digestion, glucose effect, phenotypic switching, adhesion of symbiont to host, transepithelial migration of symbiont in host, perturbation of host immune response, immune evasion, biofilm formation, single-species biofilm formation, single-species biofilm formation on inanimate substrate, fungal-type cell wall organization, and protein breakdown. The product localizes to the extracellular vesicle, fungal-type cell wall, fungal biofilm matrix, and extracellular. Related genes in other species are linked to increased virulence, loss of pathogenicity, and various forms of candidiasis.