BSC1 — Candida albicans

Summary

CaBSC1 (C1_06340W_A) on Candida albicans chromosome 1 encodes a protein containing SH3 and PX domains and is associated with phosphoinositide binding. The gene is linked to numerous biological processes including flocculation, biofilm formation, filamentous growth, mating, morphogenesis, cell adhesion, signal transduction, response to oxidative stress, fermentation, secretion, telomere localization, and TNF production. Phenotypic associations include abnormal or absent biofilm formation and flocculation, increased adhesion and mating efficiency, altered cell cycle progression, delayed cytokinesis, increased polyploidy, and reduced cell death. The gene is also associated with osmotic stress sensitivity, toxin resistance, and premature entry into stationary phase. Studies of related genes in other species link the family to flocculin and adhesion domains, as well as to polysaccharide and beta-glucan content.