IRE1 — Candida albicans

Summary

IRE1 (C1_07970C_A) on chromosome 1 of Candida albicans encodes a protein with serine/threonine kinase activity and RNA endonuclease activity, belonging to the IRE1/2-like family. The gene is associated with ER stress-induced apoptosis, positive regulation of ER-phagy, regulation of filamentous growth, cellular thermotolerance, inositol metabolism, innate immunity, type I IFN production, and cytokine production. IRE1 is localized to the ER membrane and is associated with increased virulence, abnormal carbon source utilization, increased apoptosis rate, and decreased entry into G0 phase. Related genes in other species connect it to the IRE1 branch of the unfolded protein response and oxidative stress response.