PLB1 — Candida albicans

Summary

C1_08230C_A (PLB1, also known as PLB5) in Candida albicans encodes a phospholipase with lysophospholipase catalytic domain and acyltransferase/lysophospholipase activity, specifically phospholipase A2 and phosphatidylcholine lysophospholipase A1 activities (EC 3.1.1.5). The gene is associated with host invasion, hyphal growth, germ tube formation, biofilm formation, migration in host, wound healing, inflammatory and immune responses, phagocytosis, release of cytochrome c from mitochondria, sensitization, demethylation, phosphatidylcholine acyl-chain remodeling, and phosphoglyceride catabolism. The product localizes to the periplasm, hyphal cell wall, extracellular vesicles, fungal-type cell wall, plasma membrane, endoplasmic reticulum, and cytosol. Phenotypic associations include altered endocytosis, decreased anaerobic growth, increased alkaline pH resistance, abnormal cell cycle progression, decreased apoptosis, and increased starvation resistance. Studies of related genes in other species link the family to virulence and candidiasis.