SWI6 — Candida albicans

Summary

C1_08670W_A (SWI6, also known as CDC10) in Candida albicans chromosome 1 encodes a protein of the SWI6-like family, containing APSES-type helix-turn-helix and ankyrin repeat domains, with DNA-binding, promoter-specific chromatin binding, and transcription coactivator activity. The gene is associated with regulation of morphogenesis, phenotypic switching, quorum sensing, phagocytosis, cell adhesion, and conidia formation. It is linked to the G1/S transition of the mitotic cell cycle, nuclear division, mitotic exit, and both upregulation and downregulation of transcription. Additional associations include steroid metabolism, glucan and melanin anabolism, exocytosis, and rRNA transcription. The product localizes to the nucleus, cytoplasm, chromatin, and the SBF and MBF complexes. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.