DOT — Candida albicans

Summary

C1_09990W_A (DOT, SAC1) in Candida albicans encodes a SAC domain-containing protein with phosphatidylinositol-3,5-bisphosphate 3-phosphatase, phosphatidylinositol-3-phosphatase, and phosphatidylinositol-4-phosphate phosphatase activities, among numerous inositol polyphosphate 5-phosphatase activities. The gene is associated with phosphoinositide dephosphorylation, sphingosine anabolism, plasma membrane and vacuole organization, fungal-type cell wall biogenesis, protein secretion, calcium signaling, biofilm formation, invasive and hyphal growth, and filamentous growth. It is linked to abnormal Golgi and endoplasmic reticulum distribution, decreased budding, absent peroxisomal morphology, increased endocytosis, altered nucleophagy, impaired hyperosmotic stress resistance, and absent innate thermotolerance. The product localizes to the Golgi membrane, fungal-type vacuole membrane, mitochondrial outer membrane, cell cortex, and cell tip. Related genes in other species are linked to zinc sensitivity, acid sensitivity, and oxidative stress response.