ADA2 — Candida albicans

Summary

C1_10860C_A (ADA2, also known as CaADAB, CaADA2, MYB017, or CaMYB017) on Candida albicans chromosome 1 encodes a protein belonging to the Ada2/TADA2 family and containing SWIRM, SANT/Myb, and ZZ zinc-finger domains, with transcription coactivator activity, chromatin binding, sequence-specific DNA binding, zinc binding, and phosphatidylserine binding. This gene is associated with biofilm formation, filamentous growth, hyphal growth, cell adhesion, fungal-type cell wall organization, and development of symbiont in host. It is linked to chromatin organization, telomeric silencing, rDNA heterochromatin assembly, DNA recombination, replication-born double-strand break repair, regulation of meiotic recombination, pyruvate metabolism, deubiquitination, and osmotic response. Localized to the nucleus, telomeric region, and SAGA-type, ADA, and SALSA complexes, ADA2 is associated with altered cell cycle progression, adhesion, mating-type switching, hyperosmotic stress resistance, X-ray resistance, carbon source utilization, and nutrient uptake. Related genes in other species link the family to the SAGA complex.