CDR1 — Candida albicans

Summary

C1_11400C_A (CDR1, also known as GIN4) in Candida albicans encodes a protein serine/threonine kinase with dual-specificity protein kinase activity, protein kinase A activity, and phospholipid binding, belonging to the fungal KA1 domain family. It is associated with hormone transport, response to brefeldin A and farnesol, aminophospholipid translocation, membrane polarization, reactive oxygen species anabolism, regulation of cell growth extent, spindle orientation, and mRNA transcription. The gene is linked to traits including protein content and oxidative stress response, and to phenotypes such as altered cell cycle progression through G2/M phase, premature cell cycle passage, delayed cytokinesis, decreased spore germination, abnormal filamentous growth, increased mating efficiency, and sterile outcomes. It localizes to the cellular bud neck septin ring, incipient bud site, mitotic spindle pole body, and nuclear membrane.