TRP1 — Candida albicans

Summary

C1_12210W_A (TRP1, also known as TRP3) in Candida albicans encodes a protein with anthranilate synthase, phosphoribosylanthranilate isomerase, and indole-3-glycerol-phosphate synthase activities (EC 4.1.1.48 and 4.1.3.27), and is a component of the anthranilate synthase complex in the cytosol. The gene is associated with tryptophan formation, biofilm formation, phenotypic switching, filamentous growth, chitin anabolism, and detoxification. It has been linked to numerous phenotypes including decreased resistance to gamma rays, freeze-thaw, ionic stress, UV, acid pH, and hyperosmotic stress, as well as increased chronological lifespan, increased innate thermotolerance, normal replicative lifespan, abnormal cell cycle progression, budding pattern, cell shape and size, decreased filamentous and invasive growth, decreased sporulation, decreased fermentative and respiratory growth, increased protein secretion, and abnormal protein accumulation.