SSA1 — Candida albicans

Summary

C1_13480W_A (SSA1) on Candida albicans chromosome 1 encodes a member of the Hsp70 family of molecular chaperones, possessing ATP hydrolase activity, ATP binding, peptide binding, heat shock protein binding, and protein folding chaperone functions. This gene is associated with a wide range of biological processes including germ tube formation, tropism, and responses to cadmium. It is linked to host interaction processes such as negative regulation of host defenses, inflammatory response, IL-4 production, macrophage activation, and innate immunity. Associations also include cell cycle progression, thermotolerance, chemical resistance, nutrient uptake, and fermentative growth. Studies of related genes in other species link the family to oxidative stress response and protein content.