RIM101 — Candida albicans

Summary

C1_14340C_A (RIM101, CaRIM101) on chromosome 1 of Candida albicans encodes a C2H2-type zinc-finger transcription activator of the PacC/RIM101 family. The gene is associated with DNA binding and transcription activator activity, and its product localises to both the cytoplasm and nucleus. RIM101 is linked to responses to basic pH, cellular responses to lithium ions, fluconazole transport, and the modulation of host inflammatory responses and T cell tolerance induction. It has been connected to filamentous growth, germ tube formation, cell aggregation, and pigment anabolism. Associations with calcium sensitivity and numerous cell cycle phenotypes, including delayed exit from G0 and abnormal replicative lifespan, have been noted. Studies of related genes in other species link the family to increased virulence and aspergillosis.