SOD4 — Candida albicans

Summary

C2_00660C_A (SOD4) on chromosome 2 of Candida albicans encodes a copper/zinc superoxide dismutase (EC 1.15.1.1) with superoxide dismutase activity, copper binding, and metal binding functions. The gene is associated with cellular response to superoxide, superoxide metabolism, evasion or tolerance of host-produced AOS, metabolic burst, removal of O2-, response to iron, quorum sensing, immune evasion, digestion, sumoylation, sterol metabolism, chitin anabolism, biofilm formation, cellular response to oxidative stress, hyphal growth, morphogenesis, and homeostasis. The product localizes to the yeast-form cell wall, hyphal cell wall, side of membrane, extracellular vesicle, fungal-type cell wall, cell bound, extracellular, and plasmalemma. Associations with relative growth rate and oxidative stress response have also been noted. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity.