BRG1 — Candida albicans

Summary

C2_02530W_A (BRG1) in Candida albicans encodes a transcription factor with DNA-binding transcription activator activity and sequence-specific DNA binding. This gene is associated with cell fate specification and determination, filamentous growth, chlamydospore formation, sexual reproduction, and positive regulation of sporulation. BRG1 is linked to biofilm formation, membrane depolarization, nucleosome disassembly, TOR signaling, heat response, pheromone response, sterol and chitin metabolism, glycerol anabolism, and disruption of host phagocytosis. The encoded protein localizes to chromatin and the nucleus. BRG1 is also associated with oxidative stress response. Studies of related genes in other species link the family to increased virulence and disseminated candidiasis.