ADH1 — Candida albicans

Summary

C2_04470W_A (ADH1, also known as ADH3, CaADH1, CaALCC) on Candida albicans chromosome 2 encodes a protein with ADH-like and NAD(P)-binding domains, annotated as a D-arabinitol dehydrogenase (NADP+) and aldo-keto reductase (NAD) with oxidoreductase activity acting on NAD(P)H and zinc binding. This gene is associated with alcohol breakdown, ethanal metabolism, methylglyoxal anabolism, ROS metabolic processes, glycolysis, ethanol metabolism, arginine metabolism, and nitrogen catabolite repression. It is linked to germ tube formation, tube formation, inflammatory response, clotting, response to cadmium, and glutathione anabolism. Localization evidence connects it to the cytoplasm, extracellular region, mitochondrial lumen, cell projection, and fungal biofilm matrix. Studies of related genes in other species link the family to EC 1.1.1.1 and 1.1.1.287 activities.