MKK1 — Candida albicans

Summary

C2_05780C_A (MKK1, also known as MKK2) on Candida albicans chromosome 2 encodes a protein with a protein kinase domain, ATP binding, and dual-specificity protein kinase activity annotated as MAPKK activity (EC 2.7.12.2), along with protein serine/threonine kinase and protein tyrosine kinase activities. This gene is associated with the cell integrity and pheromone response MAPK cascades, signal transduction involved in filamentous growth, germ tube formation, cell wall assembly, septin checkpoint, osmotic response, regulation of ascospore formation, and positive regulation of appressorium formation. It is linked to inflammatory response, innate immunity, immune response, upregulation of calcium-mediated signaling, and cell activation. The encoded protein localizes to the cytoplasm, nucleus, cell tip, division septum, and mating projection tip. Phenotypic associations include abnormal cell cycle progression, absent sporulation efficiency, absent cell fusion, absent alkaline pH resistance, and delayed protein secretion. Related genes in other species are linked to reduced virulence and loss of pathogenicity.