YVC1 — Candida albicans

Summary

C2_07730W_A (YVC1, CaYVC1) in Candida albicans encodes a member of the TRP calcium channel family, specifically a YVC1-like protein with LHD_YVC1 and YVC1_C domains, and exhibits calcium-activated cation channel, voltage-gated ion channel, sodium channel, potassium channel, and calcium channel activities. The gene is associated with calcium ion import, cellular calcium ion homeostasis, calcium signaling, ER stress response, oxidative stress response, and DNA replication regulation. It is linked to biofilm formation, flocculation, hyphal and invasive growth, morphogenesis, cell cycle progression, and vacuolar protein sorting. Localization evidence connects YVC1 to the fungal-type vacuole membrane, vCLAMP, and plasmalemma. The gene is also associated with disseminated candidiasis in a mouse model. Studies of related genes in other species link the family to stress resistance.