GTR1 — Candida albicans

Summary

C2_08600W_A (GTR1, CaGTR1) on chromosome 2 of Candida albicans encodes a RagA/Gtr1 family GTPase with GTP-binding and GTPase activity, and is annotated as a protein serine/threonine kinase activator. The gene is associated with regulation of TORC1 signaling (both up and down), negative regulation of autophagy, cellular responses to amino acid and nitrogen starvation, PI(3)P biosynthesis, vacuolar fusion and protein localization to the vacuolar membrane, endocytic recycling, flocculation, cell-cell adhesion, programmed cell death, and biofilm formation on inanimate substrates. It localizes to the Gtr1-Gtr2 GTPase complex, late endosome membrane, fungal-type vacuole membrane, nucleus, and cytosol. Phenotypic associations link GTR1 to abnormal carbon source utilization, altered flocculation and biofilm formation, increased or decreased cell death, absent vacuolar morphology, increased adhesion, and abnormal replicative lifespan.