OBR1 — Candida albicans

Summary

C2_08640C_A (OBR1, also known as PST2) in Candida albicans encodes a flavoprotein of the WrbA-like family with NAD(P)H dehydrogenase (quinone) activity (EC 1.6.5.2), specifically 2-hydroxy-1,4-benzoquinone reductase activity, and binds FMN. The gene is associated with plasma membrane and membrane organization, immune response, stress response, cellular response to oxidative stress, cell cycle modulation, morphogenesis, secretion, and endocytosis. Its product localizes to the eisosome, hyphal cell wall, fungal biofilm matrix, plasma membrane, cytoplasm, and nucleus. Phenotypic associations link OBR1 to cell cycle progression (including G1/S transition, S phase, metaphase-anaphase transition, anaphase, and telophase), chromosome segregation, sporulation, shmoo formation, pheromone sensitivity, bipolar budding, chitin deposition, freeze-thaw resistance, UV resistance, respiratory and fermentative metabolism, pexophagy, prion inheritance, and plasma membrane morphology. The gene is also associated with disseminated candidiasis in a mouse model.