GCN4 — Candida albicans

Summary

C2_09940W_A (GCN4) on Candida albicans chromosome 2 encodes a bZIP transcription factor with DNA-binding transcription factor activity, specifically RNA polymerase II cis-regulatory region sequence-specific DNA binding. This gene is associated with responses to amino acid starvation, hydrogen peroxide, and diamide, as well as nitrogen catabolite repression, filamentous growth regulation, germ tube formation, and biofilm formation. It is linked to threonine and lysine anabolism, phagocytosis, and cellular responses to N-acetyl-D-glucosamine. The product localizes to the nucleus and transcription regulator complex. Associations include decreased biofilm formation, abnormal cellular morphology, decreased cell size, increased autophagy, decreased alkaline pH resistance, and altered carbon source utilization. Related genes in other species are linked to reduced virulence.