ABC2 — Candida albicans

Summary

C2_09990C_A (ABC2/YOR1) in Candida albicans encodes an ABC transporter with cadmium ion transmembrane transporter, haem-transporting ATPase, and ABC-type phytochelatin and xenobiotic transporter activities, along with ATP hydrolase and metal-binding functions. The protein localises to the vacuolar membrane, plasma membrane, Golgi, and extracellular vesicles. It is associated with fluconazole transport, heme export from vacuole to cytoplasm, glutathione and PC2 import into vacuole, cellular detoxification of cadmium ion, germ tube formation, ergosterol metabolism, nitrogen utilization, mRNA transcription, and sulfur amino acid metabolism. Associations with traits include oxidative stress response, and phenotypes linked to the gene include altered vacuolar morphology and distribution, decreased endocytosis, increased pexophagy, abnormal cell cycle progression, and changes in hyperosmotic and hypoosmotic stress resistance.