ACS1 — Candida albicans

Summary

C2_10350C_A (ACS1) on Candida albicans chromosome 2 encodes a protein with amide synthase and acetate-CoA ligase activities, belonging to the AMP-binding enzyme superfamily. The gene is associated with central carbon metabolism, including acetate and acetoin breakdown, acetyl-CoA metabolism, the glyoxylate cycle, gluconeogenesis, pyruvate fermentation to acetate, and the carnitine shuttle. It is linked to protein acetylation, CoA metabolism and biosynthesis, sterol and penicillin anabolism, fruiting body formation, cell cycle modulation, and response to iron. The encoded protein localises to the cytosol, ER, nucleolus, and extracellular space. Phenotypic associations include abnormal carbon source utilization, decreased hypoosmotic stress resistance, absent adhesion, altered pheromone production and sensitivity, delayed cell cycle progression, increased X-ray resistance, and abnormal spore wall formation. Studies of related genes in other species link the family to protein content.