DOG1 — Candida albicans

Summary

C3_00320W_A (DOG1, also known as RHR2) in Candida albicans encodes a sn-glycerol 3-phosphatase with sugar-phosphatase and metal-binding activities, belonging to the HAD-superfamily hydrolase family. The gene is associated with glycerol anabolism and metabolism, osmotic and cellular osmotic responses, biofilm formation, morphogenesis, host invasion, immune evasion, cell-cell signaling, and cytoskeleton organization. It has been linked to increased virulence, decreased hypoosmotic stress resistance, increased acid pH resistance, increased starvation resistance, decreased apoptosis, decreased invasive growth, increased flocculation, and altered cell cycle progression. Associations with disseminated candidiasis in mouse models and a salt tolerance trait have also been noted. Studies of related genes in other species connect the family to oxidative stress response and fungal meningitis.