HH3 — Candida albicans

Summary

C3_00860W_A (HH3, also known as CSE4) in Candida albicans chromosome 3 encodes a histone H3/CENP-A family protein that is a structural constituent of chromatin and binds nucleosomal DNA, centromeres, and heterodimerization partners. The gene is associated with centromere and kinetochore assembly, CENP-A-containing chromatin assembly and localization, mitotic metaphase chromosome alignment, centromere separation, anaphase progression, chromosome segregation, and meiosis. It is linked to mating type switching, gene conversion, chromatin silencing, and methylation. Phenotype associations include delayed cell cycle progression in mid-anaphase and telophase, decreased duration in metaphase and anaphase, premature metaphase-anaphase transition, decreased G2/M phase transition, increased G1/S transition, altered S phase rate, increased sporulation and meiosis rates, increased gamma ray resistance, decreased hypoosmotic stress resistance, and abnormal mitophagy and pheromone-induced cell cycle arrest. The protein localizes to the nucleosome, centromeric core domain, kinetochore, and peroxisome.